A $1.00 (€0.90) increase (decrease) in the assumed public offering price of
$42.43 per ADS in the U.S. offering and €38.05 per ordinary share in the
European private placement would increase (decrease) our net proceeds from the
global offering by $4.4 (€3.9) million, assuming the number of shares and ADSs
offered by us, as set forth on the cover page of this prospectus, remains the
same and after deducting underwriting discounts and commissions. Each increase
or decrease of 1,000,000 shares and ADSs in the aggregate number of shares and
ADSs offered by us would increase or decrease the net proceeds to us from the
sale of the shares and ADSs we are offering by $39.5 (€35.4) million, assuming
that the assumed public offering price remains the same and after deducting
underwriting discounts and commissions. Each increase of 1,000,000 shares and
ADSs in the aggregate number of shares and ADSs offered by us together with a
concomitant $1.00 (€0.90) increase in the assumed public offering price of
$42.43 per ADS in the U.S. offering and €38.05 per ordinary share in the
European private placement, would increase the net proceeds to us from the sale
of the shares and ADSs we are offering by $44.8 (€40.2) million, after deducting
underwriting discounts and commissions. Each decrease of 1,000,000 shares and
ADSs in the aggregate number of shares and ADSs offered by us together with a
concomitant $1.00 (€0.90) decrease in the assumed public offering price of
$42.43 per ADS in the U.S. offering and €38.05 per ordinary share in the
European private placement would decrease the net proceeds to us from the sale
of the shares and ADSs we are offering by $42.9 (€38.5) million, after deducting
underwriting discounts and commissions. The actual net proceeds payable to us
will adjust based on the actual number of shares and ADSs offered by us, the
actual public offering price and other terms of the global offering determined
at pricing.