Tom3 schreef op 7 juni 2021 09:28:
Het uitschakelen van het PCSK9 gen lijkt ook (niet onderkende?) gevolgen te hebben voor de rest van je lichaam. Dit pleit er voor rnai te gebruiken zodat je het nog sturen (naar analogie van Revusiran):
knockout of PCSK9 - concerns
Nabil G. Seidah, a cardiovascular biologist at the Clinical Research Institute of Montreal who discovered PCSK9’s role in cholesterol signaling in 2003, notes that the gene has other functions besides cholesterol regulation. For example, it appears to play a role in immunity and is also expressed in unexpected places, like the testes and the pancreas, hinting of roles researchers have not yet identified.
Permanently disabling it with CRISPR may therefore have unforeseen effects, he says. “When you do the CRISPR, you’re stuck,” he says. “What’s the antidote?”.