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J&J neemt 18$ belang in Crucell voor 301mln

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aossa
0
quote:

josti5 schreef:

'De moeite niet waard :-('

Deugniet -;)
Wacht nog even, de optiehandelaren zijn volop contracten aan het sluiten :-D
josti5
0
':-#}'

Hee rakker Wilb, gij waart even op dit forum, dus...

Nog bewustzijnsverruimende inzichten voor de komende Crucell-tijd, nu het stof weer neergedwarreld is?

Kom er maar weer eens in, beste kerel:

By the way: dit weekeinde bruiloft op US-basis in Heidelberg.
TraderRon
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Ben benieuwd wanneer we enig zich krijgen op de overname target van Crucell.

Ik kan me bijna niet voorstellen dat ze pas met onderhandelen begonnen zijn na het bekend maken van deze deal.
Dat zou zeker gezien de uitspraken van Brus alleen maar koersopdrijvend werken.

Een overname in de UK lijkt me niet aangezien ze daar net een verkoop team opgetuigd hebben en ze anders gewoon gebruik kunnen maken van het verkoop team van de overname kandidaat.

Laten we hopen dat er enige duidelijkheid is voor de q3 cijfers.
[verwijderd]
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quote:

TraderRon schreef:

Ben benieuwd wanneer we enig zich krijgen op de overname target van Crucell.

Ik kan me bijna niet voorstellen dat ze pas met onderhandelen begonnen zijn na het bekend maken van deze deal.
Dat zou zeker gezien de uitspraken van Brus alleen maar koersopdrijvend werken.

Een overname in de UK lijkt me niet aangezien ze daar net een verkoop team opgetuigd hebben en ze anders gewoon gebruik kunnen maken van het verkoop team van de overname kandidaat.

Laten we hopen dat er enige duidelijkheid is voor de q3 cijfers.
Volgens mij wil Brus iets in de USA kopen.

Take a pick.

Dirk

en.wikipedia.org/wiki/List_of_pharmac...
aossa
0
quote:

Dirk R. Wijnen schreef:

Of uit dit lijstje?
www.violinet.org/vaxcom/index.php
Als ik mag kiezen dan kies ik 'Novartis Vaccines & Diagnostics', hebben we direct 100% winst binnen op QV ipv de huidige 50% en een poot op Indisch continent via Panacea.

Tweede voorkeur 'Baxter Bioscience' omdat dit reeds vroeger genoemd is ivm bloedziekten.

BTW. verdeelt Crucell nog steeds een bloed-medicijn, ooit genoemd als opstapje naar meer en beter in bloed?

aossa
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J&J Tries to Buy Itself a Pipeline
It's snapping up biotechs, spearheading innovative alliances, and reshuffling R&D

A year ago, when Sheri S. McCoy was picked to lead Johnson & Johnson's (JNJ) pharmaceutical division, she knew it would be the biggest challenge she had faced in 27 years at the company. J&J was losing patent protection on two giant products: treatments for epilepsy and schizophrenia. It didn't have a single product on the near horizon that could make up for the $7 billion in annual sales that would disappear when the two drugs went generic.

So McCoy, like many pharmaceutical managers, poured her energies into acquisitions, partnerships, and novel research collaborations, hoping to gain faster access to promising new markets. In July, J&J devoured Cougar Biotechnology for close to $1 billion. In early September it spent $885 million for an 18% stake in Elan Pharmaceuticals (ELN). And J&J will pay $441 million for 18% of Crucell (CRXL), a Dutch biotech company that's developing vaccines—a new product line for the 123-year-old J&J. This last purchase was announced on Sept. 28, the same day rival Abbott Labs (ABT) bought the drug and vaccine unit of Belgium's Solvay (SVYSY) for $6.6 billion. Deals like these are unusual for J&J, but CEO William C. Weldon says McCoy has his full support. "We try to do our best with our internal research," he told BusinessWeek, "but we recognize we need to look at other opportunities."

McCoy's mandate isn't confined to mergers and acquisitions. She is responsible for all aspects of drug development, from spotting potential hit molecules to devising marketing tactics. Laying out a strategy is challenging now, with the recession dampening pharmaceutical sales and debates over health-care reform raising questions about how drug companies will be reimbursed. In the first half of 2009, sales of J&J's prescription drugs dropped 12% from the same period a year ago, to $11.3 billion. Revenues also fell in J&J's consumer and medical-device units as customers kept their wallets shut. And J&J has had some regulatory setbacks: The Food & Drug Administration has issued a slew of requests for more data on drugs the company has submitted for review.
Strange Bedfellows

One of McCoy's most controversial moves is the deal with Irish drugmaker Elan. She and her team were interested in a promising treatment for Alzheimer's disease in Elan's pipeline, but Elan already had a research partnership with Wyeth (WYE), which is being acquired by Pfizer (PFE). The deal thus plunges the normally conservative J&J into an unusual three-way research alliance. In the past, Weldon says, rivalry might have scuttled the partnership plan, but not anymore. "The cost of bringing products to market and the risk associated with them is so much greater in today's environment," he explains. Success may depend on "the ability to partner."

J&J initially agreed to invest $1 billion in Elan, but on Sept. 14 it had to renegotiate the price and restructure the deal to avoid violating Elan's contract with another partner. Even at the lower valuation, however, it's a risky bet, especially considering that Elan's lead drug has had mixed results in clinical trials. Investors were concerned that "the implied value was on the high side," says Sara C. Michelmore, an analyst for Cowen & Co, which does not have an investment banking relationship with J&J. "But gosh, it's about portfolio management." J&J needs some high-risk, high-reward products in its pipeline, she says.

J&J also has been shopping for companies to acquire outright—and there are plenty of cash-strapped biotechs searching for lifeboats. Cougar was one. The $953 million J&J paid in cash was a huge premium for a startup that's years away from having a commercial drug. But McCoy was impressed with the company's method of treating prostate cancer by inhibiting enzymes involved in hormone production—an approach that might also work in breast cancer. J&J hopes to enhance Cougar's method with technology from another subsidiary, Veridex, that lets oncologists count tumor cells in the bloodstream to assess how well treatments are working. Using this in clinical trials, "we think we'll be able to predict which patients will benefit from the drugs," McCoy says.

Even as the company explores partnerships, McCoy keeps her eye on internal research. One goal is to make the organization more entrepreneurial. In the past, J&J separated research and development by function—basic research, clinical, regulatory, and so forth. Instead, McCoy has set up five units defined by therapeutic focus: neurology, infectious disease, immunology, oncology, and cardiovascular and metabolic disease. Each unit has its own scientists and specialists versed in dealing with the FDA. And each has researchers dedicated to developing tests that will help doctors identify the patients most likely to respond to a new drug.

McCoy, who came up through J&J's consumer and medical-device divisions, concedes she may have blind spots when it comes to prescription drugs, but she's undaunted by her new challenge. "I'm never going to have the depth of expertise" in drugs, she says. "But I'm comfortable making decisions in a time of ambiguity."

Weintraub is a senior writer for BusinessWeek's Science & Technology department.

www.businessweek.com/magazine/content...
===============
Als ik het goed begrijp dan zit Elan in hetzelfde schuitje als Crucell, in beiden heeft J&J onlangs een participatie van 18% genomen

Zit er wat kruisbestuiving in?
aossa
0
JANSSEN Alzheimer Immunotherapy

Elan and Johnson & Johnson announced on September 17, 2009, that JANSSEN Alzheimer Immunotherapy, a Johnson & Johnson affiliate, had acquired substantially all of Elan’s assets related to the Alzheimer’s Immunotherapy Program (AIP). Elan holds a 49.9% equity interest in JANSSEN Alzheimer Immunotherapy, and will be entitled to a 49.9% share of the profits and certain royalty payments upon the commercialization of AIP products under a collaboration with Wyeth.

JANSSEN Alzheimer Immunotherapy will continue the AIP activities in a collaboration with Wyeth to research, develop and commercialize selective products for the treatment and/or prevention of neurodegenerative conditions, including Alzheimer's disease. The program includes multiple compounds being evaluated for slowing the progression of Alzheimer's disease.

The lead compound (bapineuzumab), a potential first-in-class treatment that is being evaluated for slowing the progression of Alzheimer's disease, is administered intravenously once every three months and is currently in Phase 3 clinical trials. A subcutaneous formulation, administered once a week, is currently in Phase 2 trials. In addition, a vaccine for Alzheimer's disease (ACC-001) is also under development.

www.elan.com/company/
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J&J Bets on Vaccines

Posted by: Arlene Weintraub on October 01

How smart is it for a century-old company to buy its way into a new product line rather than trying to build it from the ground up? If you’re Johnson & Johnson, a company with $9.5 billion in free cash, it might prove to be very smart. On September 28, J&J bought an 18% stake in Dutch vaccine maker Crucell for $441 million—marking J&J’s first entrée ever into vaccines. Over the summer, J&J bought biotech company Cougar for nearly $1 billion, instantly boosting J&J’s limited in-house expertise in oncology. Sure, the two deals brought J&J a couple of late-stage pipeline products, but what makes them most valuable is that they infused the health-care conglomerate with capabilities it did not have before.

Take Crucell, for example. The Leiden, Netherlands based company is working on a universal monoclonal antibody against flu—a biotech vaccine that could potentially protect patients against all strains of influenza A, including swine flu. But this partnership wasn’t just about one product: Paul Stoffels, J&J’s global head of research and development, says Crucell offers the complete package of what J&J needs to take a leadership position in vaccine development. In addition to the promising experimental flu vaccine, it offers technology for making the booster shots that are required in many vaccination programs, as well as a widely applicable production platform. Crucell engineered a cell line that can pump out antibodies at very high yields, possibly providing an alternative to the stodgy method of making vaccines in eggs. “Moving from egg-based to cell-based production is a critical shift,” Stoffels says. And J&J has expertise to offer Crucell, as well. “Crucell does basic research, we do global development. We can be complimentary.”

This may be exactly the right time for J&J to be taking some big risks. With the recession pushing sales down in all three of its major divisions—prescription drugs, medical devices, and consumer products—the company needs to find new opportunities for growth.

Crucell and Cougar are part of a string of recent deals that started with J&J’s December purchase of medical-device maker Mentor. Now some analysts are wondering if the company is warming up to make a really big buy. In a Sept. 17 report, Credit Suisse analyst Catherine J. Arnold suggested that J&J is among the drugmakers that should consider a major acquisition, because companies with “more diversification could benefit from augmentation of revenue growth,” she wrote. She pointed out that J&J could easily pick up a company like Vertex, with which it is co-developing a promising Hepatitis C drug. Vertex has a market valuation of $6.6 billion, making it rather big bite for a company that tends to shy away from earthshaking deals. (J&J’s biggest acquisition ever was its 2006 purchase of Pfizer’s consumer health division, for $16.6 billion.)

During lunch at J&J’s headquarters a few weeks before the Crucell deal was announced, J&J CEO William Weldon reflected on the challenges of dealmaking during a recession. “I don’t think we look at things any differently than we ever have,” he says. “The question is can we create shareholder value, does the deal accelerate growth in the short and long term, does it put us into good therapeutic areas?” When it comes to really big mergers, akin to Pfizer’s plan to buy Wyeth for $68 billion, the answer is usually no, Weldon says. “Mega-deals have just not been the way we’ve chosen to do acquisitions.”

Weldon says that J&J will continue to be conservative when it comes to thinking about all deals, even though valuations had dropped considerably during the recession. He fears that acquiring companies that are down-and-out might actually be more risky than buying healthy assets. “There are a lot of companies that cannot raise capital to get products further along on their own, so they may be for sale earlier,” he explains. “That means there’s more risk associated with the acquisition, and more costs after you acquire it.”

Many industry experts agree with Weldon’s assessment, and they expect he’ll continue to look for small but valuable assets to add to its stable of well-known products. “J&J is like the mutual fund of health care,” says Eric Gordon, professor at the University of Michigan Ross School of Business. “They’ve got hip replacement, stents, Neutrogena. Buying Cougar is not like Pfizer buying Wyeth. It’s not about combining salesforces,” or making other consolidation-like moves to save money, Gordon sayss. “J&J is purely buying oncology and biotech capabilities. It’s totally consistent with their approach.”

What’s more, Gordon points out, J&J isn’t hoarding cash like a company considering a big purchase might: J&J increased its dividend last year and again this year, and it has been buying back its own shares over the last three years. So while J&J could very well continue its buying spree, it’s likely to nibble at small targets, rather than gobbling up giant assets.
aossa
0
Crucell: geen impact op contract Sanofi
28 september 2009, 9:37 | ANP

AMSTERDAM (AFN) - De samenwerking die biotechnologiebedrijf is aangegaan met het Amerikaanse Johnson & Johnson tast het contract dat Crucell heeft met het Franse Sanofi-Aventis niet aan. Dat zei topman Ronald Brus van Crucell maandag in een toelichting. Volgens Brus voert Crucell op een ander gebied onderzoek uit met Sanofi dan straks met Johnson & Johnson.

Johnson & Johnson neemt een belang van circa 18 procent in Crucell door voor ruim 300 miljoen euro aan nieuwe aandelen te kopen. Brus liet weten dat geld goed te kunnen gebruiken voor nieuw innovatief onderzoek.

Daarnaast toonde de topman zich zelfverzekerd over de mogelijkheden van Crucell om snel nieuwe griepvaccins op de markt te kunnen brengen. Volgens Brus heeft Crucell een voorsprong op andere bedrijven in de ontwikkeling van het product. Hij wilde echter niets zeggen over een eventueel tijdschema.
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1
al geplaatst?


Crucell NV
15,380 ( 01/10 )



A. van Herk meldt belang 8,60% in Crucell - Wft
01-10-2009 07:32:00

AMSTERDAM (Dow Jones)--Aat van Herk heeft een belang van 8,60% in Crucell nv. Dit blijkt donderdag uit een melding in het kader van de Wet op het financiele toezicht (Wft).

De meldingsplicht is ontstaan op 28 september 2009. Het belang wordt middellijk reeel gehouden via Onroerend Goed Beheer- en Beleggingsmaatschappij A. van Herk bv en bestaat uit 6.986.185 gewone aandelen. Het stemrecht bedraagt 8,60%.

De vorige melding van Van Herk in Crucell dateert van 11 augustus 2009. Toen bedroeg het belang 10,15%, bestaande uit 6.754.335 gewone aandelen.

Crucell kondigde op 28 september 2009 aan dat Johnson & Johnson (J&J) een belang van 18% in Crucell nv heeft genomen middels de aankoop van 14,6 miljoen nieuwe aandelen van het Leidse biotechbedrijf.

- Door Martijn Mom; Dow Jones Nieuwsdienst; +31-20-5715 201; martijn.mom@dowjones.com

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1
Crucell, 'defensief aandeel'. In deze marktsituatie mag je verwachten dat crucell goed blijft liggen?
flosz
2
Johnson & Johnson: Well Positioned for Growth

A Knocking Opportunity Answered
We believe Johnson & Johnson (JNJ) is making all the right moves, and at the right time. Its healthy balance sheet, cash horde and consistent cash flow generation has empowered the company to exploit significant opportunities created by the worldwide recession. Through numerous small strategic acquisitions and opportunistic partnerships, Johnson & Johnson is beefing up its already strong pharmaceutical segment.

Expanding Pharmaceutical Segment
Representing appropriately 39% of revenues, the pharmaceutical segment is J&J's largest and perhaps most important business unit. Generic competition sales have recently slowed growth considerably, but Johnson & Johnson is aggressively meeting the challenge. With an already promising pipeline of numerous compounds in high growth markets and many in late stages of development, the company is well positioned to mitigate the generic threat to future growth. Furthermore, its recent acquisitions and alliances should greatly enhance their biopharma pipeline into major growth areas. For example, the recent deal with Elans’ Alzheimer’s program gives J&J access to the third largest market relative to cost of treatment behind only cardiovascular disease and cancer. A recent deal with Crucell NV brings monoclonal antibodies and vaccines, both very attractive growth markets
seekingalpha.com/article/164353-johns...
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28 sep 09, 08:54

quote:

wilb52 schreef:

Dit wordt een gap-up op de weekgrafiek die, lange tijd niet meer geclosed gaat worden, ala 8-4-2005!
Warempel een ware kenner!En ook zo consequent.
flosz
1
Johnson & Johnson (NYSE:JNJ): Third Quarter Earnings Preview 2009
Johnson & Johnson is scheduled to report third-quarter financial results and review its medical devices & diagnostics business on Tuesday, Oct. 13, 2009. In the last four quarters, the company has managed to surprise the investors by reporting higher earnings than the market's consensus.
Analysts' estimates for the quarter ending September 2009 (Q3) range from a low of $1.06 to a high of $1.17, with a consensus of $1.128. Since 2004, the company's Q3 revenue has been lower than its Q2 revenue. May be we can see a trend reversal.
For the third quarter of 2009, sales for the over-the-counter pharmaceuticals and nutritional could increase by 0.2% on an operational basis compared to the same period in 2008 with similar results both in and outside the U.S. Intensified competitive pressures including private label have impacted the growth in this category.
The skincare business should achieve operational sales growth of 5.5% in the third quarter of 2009 with sales in the U.S. growing at 7.5% and sales outside the U.S. up 4% on an operational basis. Baby care products could decline by 3% on an operational basis when compared to the third quarter of 2008. Women's health could achieved operational sales growth of 4.6%.
The company's results continue to be impacted by generic competition on some of its products, namely RISPERDAL Oral, [RAZADINE], and TOPAMAX. The marketing exclusivity for RISPERDAL expired in the U.S. at the end of June 2008 and there are generic competitors for RISPERDAL in most markets. The marketing exclusivity for TOPAMAX expired at the end of March this year and multiple generics have entered the market while generic competitors for [RAZADINE] entered the U.S. market in the latter half of 2008.
The combined impact of these three products continues to reduce the third quarter worldwide pharmaceutical operational growth rate by approximately 18 points, with the U.S. impact estimated at over 27 points and the impact outside the U.S. estimated at 3 points.
The sales of REMICADE, a biologic approved for the treatment of a number of immune mediated inflammatory diseases, could be up 25% when compared to the third quarter of 2008. Sales of PROCRIT/EXPREX continue to decline. Sales of LEVAQUIN, could be up 4.5%. I also expect RISPERDAL CONSTA, and CONCERTA to register higher sales in the third quarter.
In September 2009, JANSSEN Alzheimer Immunotherapy, a newly formed subsidiary of Johnson & Johnson, completed the acquisition of substantially all of the assets and rights of Elan related to its Alzheimer's Immunotherapy Program (AIP). Also in the same month, Johnson & Johnson , through its subsidiary Ortho-McNeil-Janssen Pharmaceuticals, Inc., and Crucell entered into a strategic collaboration focusing on the discovery, development and commercialization of monoclonal antibodies and vaccines for the treatment and prevention of influenza and other infectious and non-infectious diseases. In the current month, Johnson & Johnson's new once-monthly arthritis drug Simponi got European health regulators approval.
Though, the company's revenues could be lower in 2009 compared to 2008, I see the topline developing nicely over the next three to five years. Currently, the stock is trading at $60.29, compared to the 52 week range of $46.25-$67.48. The stock seems to be valued appropriately at the current levels
www.istockanalyst.com/article/viewart...
flosz
2
Tom Heyman (Janssen Pharma): "Overname UCB is problematisch"

07/10/2009 15:00
De farmagroep UCB wordt door analisten, gepolst door Trends en Cash, naar voren geschoven als een van de grootste Belgische overnameprooien. De farmagroep Janssen Pharmaceutica en diens moederbedrijf Johnson & Johnson zeiden eerder al neen tegen zopas verkochte Solvay Pharma, en zien ook een overname van UCB niet zitten. Dat gaf Janssen Pharma-topman Tom Heyman aan tijdens de Trends Inside Lunch.

"UCB heeft een aantal producten die in dezelfde therapeutische domeinen liggen als producten die wij hebben", zegt Heyman. "Dat levert heel wat problemen op rond goedkeuring en mededinging. Als we niet sneller groeien door een overname, creëren we geen meerwaarde, maar vernietigen we alleen maar waarde."

Heyman kwam ook terug op de overname van Solvay Pharma door het Amerikaanse Abbott. "We zijn benaderd zoals iedereen, hebben er naar gekeken, en zijn tot de conclusie genomen dat het niet paste in onze strategie. We hebben beslist om eerder te investeren in echt therapeutische innovatieve producten."

Heyman wijst er op dat J&J recent een belang van 18 procent heeft gekocht in het Nederlandse biotechbedrijf Crucell, dat werkt aan de ontwikkeling van een universeel griepvaccin. J&J heeft verder ook fors geïnvesteerd in het Ierse biotechbedrijf Elan, dat medicijnen tegen de ziekte van Alzheimer ontwikkelt. "Zij hebben een product in fase drie (de laatste ontwikkelingsfase voor registratie, nvdr). "Als dat er komt, is dat werkelijk revolutionair", zegt Heyman.
www.trends.be/nl/economie/bedrijven/4...
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Uit

www.marketwatch.com/story/jj-results-...

*************
In September, the conglomerate said it was buying an 18% stake in Dutch vaccine specialist Crucell N.V. J&J is buying an 18% stake in Irish drug developer Elan Corp. , and plans to invest heavily in that company's Alzheimer's drug program.

In May, J&J announced it was acquiring oncology drug developer Cougar Biotechnology for $1 billion in cash. Early this year, the company bought Mentor Corp., a leading maker of such cosmetic products as breast implants, for just over $1 billion.

+++++++++++++++++++++++++++++++
"There are reasons for optimism going into 2010," said Funtleyder, referring in particular to the Mentor and Crucell deals.
+++++++++++++++++++++++++++++++

The analyst added that J&J's new blood-thinner, Xarelto, could also prove to be a big money-maker. The product is still awaiting U.S. regulatory approval.

"I think it should get approved," said Funtleyder. "It has blockbuster potential."

Val Brickates Kennedy is a reporter for MarketWatch in Boston.
flosz
0
Johnson & Johnson Reports 2009 Third-Quarter Results:

Sales of $15.1 Billion Decreased 5.3% Versus 2008 Third Quarter
EPS of $1.20 increased 2.6% Versus 2008 Third Quarter

Early in the fourth quarter, the Company announced that it had entered into a strategic collaboration with Crucell, N.V., focusing on the discovery, development and commercialization of monoclonal antibodies and vaccines for the treatment and prevention of influenza and other infectious and non-infectious diseases. The agreement also included an 18% equity investment in Crucell, N.V.

files.shareholder.com/downloads/JNJ/7...

Oct 13, 2009
8:30 AM ET Johnson & Johnson Third Quarter 2009 Earnings Meeting
Speaker(s): Alex Gorsky, Worldwide Chairman, Medical Devices & Diagnostics, Dominic Caruso, Vice President, Finance and Chief Financial Officer, and Louise Mehrotra, Vice President, Investor Relations
www.investor.jnj.com/webcasts-present...
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