Amgen is tevreden over haar vorderingen met Olpasiran getuige dit fragment uit hun laatste earnings call:
Operator
Your next question is from Jay Olson with Oppenheimer.
Jay Olson
Oh, hey, thanks for taking the question. I’m curious about the Phase 2 data for Olpasiran that you expect in the first half of next year. Can you just talk about what sort of signals you’ll be looking for in that data, in terms of your plans to design a Phase 3 study and any potential points of differentiation from Pelacarsen? Thank you.
David Reese
Yeah, thanks, Jay. And for those who may not know off the top of their heads, what Olpasiran is, this was formerly AMG 890. It’s small interfering RNA, designed to lower lipoprotein(a) levels in patients with atherosclerotic cardiovascular disease, where elevated LP little a may be a driver.
As we noted, we completed enrollment in what’s a robust Phase 2 trial that actually completed enrollment ahead of schedule. And what we’ll be looking for, as we unveil those data, Jay, are first of all, longer-term follow-up, meaning sufficient long-term suppression of Lp(a) levels and our targets would be in the range of the Phase 1 data that we presented last November, at the American Heart Association meeting, and then of course, additional safety data.
And of course, we are exploring different dose levels, as is pretty much standard in a program like this. And so, this would be in part for dose selection for Phase 3 going forward. We are very actively engaged already in Phase 3 planning and what the design of that sort of trial may look like.
Based on the data that we’ve seen to date, one of our goals may be relatively infrequent dosing, given the duration of effect that we observed in the Phase 1 trial. And that’s one thing that we’ll be taking a close look at, as well in Phase 2.